Thermo Fisher Scientific FADD Polyclonal Antibody
FADD 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에서 반응합니다. Western blot, ELISA, Immunoprecipitation에 적합하며, 고순도 Affinity Chromatography 정제 제품입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 200 µg–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–208 of human FADD (NP_003815.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.34 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901657 |
Product Specific Information
- Positive Samples: 293T, MCF7, HeLa, Mouse liver, Mouse kidney, Mouse heart
- Immunogen Sequence:
MDPFLVLLHS VSSSLSSSEL TELKFLCLGR VGKRKLERVQ SGLDLFSMLL EQNDLEPGHT ELLRELLASL RRHDLLRRVD DFEAGAAAGA APGEEDLCAA FNVICDNVGK DWRRLARQLK VSDTKIDSIE DRYPRNLTER VRESLRIWKN TEKENATVAH LVGALRSCQM NLVADLVQEV QQARDLQNRS GAMSPMSWNS DASTSEAS
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas receptor, TNFRSF25, and TNFSF10/TRAIL receptor, participating in death signaling initiated by these receptors. Interaction with receptors exposes the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice suggest its importance in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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