Thermo Fisher Scientific Integrin beta 7 Polyclonal Antibody
Human 및 Mouse 반응성을 가진 Rabbit Polyclonal Integrin beta 7 항체로, Western Blot과 ELISA에 적합합니다. 재조합 단백질(aa 1-140)을 면역원으로 사용하였으며, 액상 형태로 제공됩니다. 염증 반응 중 백혈구 부착 및 이동 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–140 of human ITGB7 (NP_0008801) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901660 |
Product Specific Information
- Positive Samples: HT-29, THP-1, LO2, Mouse lung, Mouse thymus
- Immunogen sequence:
MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL
Target Information
Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the α4β7 integrin (LPAM-1), expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the αEβ7 integrin (HML-1), expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes.
Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1, and fibronectin, while the ligand of HML-1 is E-cadherin (CD324).
Integrin beta 7 plays a crucial role in leukocyte adhesion to endothelial cells, promoting transmigration to extravascular spaces during inflammatory responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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