Thermo Fisher Scientific ZNF521 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZNF521. Recombinant protein control fragment (Product #RP-93654). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZNF521,uniProtId:Q96K83-1,ncbiNodeId:9606,antigenRange:347-429,antigenLength:1311,antigenImageFileName:PA5-54898_ZNF521_Q96K83-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54898_ZNF521_Q96K83-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Lot-Specific

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2650172

Product Specific Information

Immunogen sequence: VTVGYTSVSS TTPDSNLSVD SSTMVEAAPP IPKSRGRKRA AQQTPDMTGP SSKQAKVTYS CIYCNKQLFS SLAVLQIHLK TMH

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.