Thermo Fisher Scientific ZNF521 Polyclonal Antibody
ZNF521 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료 반응성, IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 액상 형태. 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZNF521. Recombinant protein control fragment (Product #RP-93654). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Lot-Specific |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2650172 |
Product Specific Information
Immunogen sequence:
VTVGYTSVSS TTPDSNLSVD SSTMVEAAPP IPKSRGRKRA AQQTPDMTGP SSKQAKVTYS CIYCNKQLFS SLAVLQIHLK TMH
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains.
It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors.
ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association, and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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