Thermo Fisher Scientific NR0B2 Monoclonal Antibody (OTI5F10), TrueMAB
인간 NR0B2 단백질을 인식하는 Mouse IgG2a 단클론 항체. Western blot에 적합하며, TrueMAB 형식으로 1 mg/mL 농도의 액상 시약. Affinity chromatography로 정제되어 안정적인 신호 재현성 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution
- 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5F10 |
| Immunogen | Full length human recombinant protein of human NR0B2 produced in E.coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain.
It belongs to the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones.
Some members of this family are orphan nuclear receptors without known ligands.
The NR0B2 protein interacts with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation.
It also interacts with estrogen receptors, leading to inhibition of their function.
Studies suggest that NR0B2 represses nuclear hormone receptor-mediated transactivation via two mechanisms:
- Competition with coactivators
- Direct transcriptional repressor activity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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