Thermo Fisher Scientific GAD2/GAD65 (GABAergic Neuronal Marker) Recombinant Rabbit Monoclonal Antibody (rGAD2/9382)

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rGAD2/9382

Immunogen

Recombinant human GAD2 (GAD65) protein fragment (around aa 1-200). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:GAD65,uniProtId:Q05329-1,ncbiNodeId:9606,antigenRange:1-200,antigenLength:585,antigenImageFileName:2572-MSM11-P0_GAD65_Q05329-1_Rabbit.svg,antigenImageFileNamePDP:2572-MSM11-P0_GAD65_Q05329-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:Human pancreas or brain (IHC).

Cellular Location: Cytoplasm.

Target Information

GAD65 (glutamic acid decarboxylase-65) are present in autoimmune disorders such as insulin-dependent (type1) diabetes mellitus (IDDM), stiff man syndrome and polyendocrine autoimmune disease. Auto-antibodies to GAD65 are present in 60-70% of individuals with newly diagnosed IDDM and thus are important markers for disease activity. These auto-antibodies usually recognize conformation-dependent regions on GAD65 and rarely bind to the second isoform, GAD67. Auto-antibodies to GAD67 are found in only 15% of recent-onset IDDM patients and most of this binding can be blocked with GAD65, suggesting shared epitopes between the two isoforms of GAD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.