Thermo Fisher Scientific Phospho-STAT1 (Tyr701) Polyclonal Antibody
STAT1 단백질의 Tyr701 인산화 상태를 검출하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF, ChIP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 5 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
| ChIP assay (ChIP) | 10 µL | - |
| Dot blot (DB) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from the region of mouse STAT1 containing tyrosine 701 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533642 |
Target Information
STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. It can be activated by interferon-alpha, interferon-gamma, EGF, PDGF, and IL6. STAT1 regulates genes involved in cell growth, apoptosis, immune responses, and lipid metabolism, and plays a role in cell viability in response to stimuli and pathogen exposure.
The STAT1 gene is located on chromosome 2. Upon phosphorylation by JAK tyrosine kinases, STAT1 translocates to the nucleus to regulate transcription of numerous genes. Among the seven STAT types, STAT1, STAT3, STAT5a, and STAT5b have broad activation profiles. STAT1 is activated by ligands including IFN family (IFN-α, IFN-β, IFN-γ, IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, G-CSF), and receptor tyrosine kinases (EGF, PDGF, CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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