Thermo Fisher Scientific NOTUM Polyclonal Antibody
NOTUM 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. Human, Mouse, Rat에 반응하며 Protein A로 정제됨. 고순도 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human NOTUM (amino acids 351–450) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Genetic studies in Drosophila have revealed a novel secreted antagonist for Wingless (Wg) signaling, referred to as Notum/Wingful (Wf). Wf/Notum encodes a protein of 430 amino acid residues, related to plant pectin acetylesterases of the α/β-hydrolase superfamily. The main target of Notum action appears to be cell surface proteoglycans Dally and/or Dally-like (Dlp). Notum governs extracellular Wg morphogen distribution via Dally and Dlp. Like some vertebrate Wnt antagonists, notum expression is activated by Wg signaling, revealing a feedback control mechanism in which Wg modifies its own gradient distribution. In vertebrates, proteoglycans related to Dally and Dlp likely play important roles in Wnt signaling, encoding a glypican required for Wnt-11 signaling. A single ortholog of Notum exists in mouse and human genomes, suggesting a similar regulatory mechanism may exist in vertebrates.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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