Thermo Fisher Scientific FASLG Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

in situ PLA (PLA)

• Tested Dilution: 1:1200

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

Target Information

CD178 (Fas ligand, FasL) is a type-II membrane protein whose N-terminus is in the cytoplasm and C-terminal region extends into the extracellular space. Its receptor, FasR, is a cell-surface type-I membrane protein and a member of the tumor necrosis factor (TNF) and nerve growth factor (NGF) receptor family.
As a member of the TNF-cytokine family, CD178 induces apoptosis when interacting with FasR. CD178 may exist as either membrane-bound (45 kD) or soluble forms (26 kD). The soluble protein can be released from cells upon cleavage by metalloproteinases.

Binding of CD178 to Fas leads to oligomerization of the receptor and triggers apoptotic cell death through the interaction of other proteins. CD178 is predominantly expressed in activated T-lymphocytes and natural killer (NK) cells, and also in immune-privilege tissues such as testis and eye. Expression has been reported in thymus, liver, ovary, lung, heart, and kidney.

CD178-mediated apoptosis is involved in anti-viral immune responses. It plays a role in immune regulation and T cell-mediated cytotoxicity, and is associated with atherosclerosis and inflammatory diseases. The Fas/CD178 system is implicated in various human diseases such as AIDS, hepatitis, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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