Thermo Fisher Scientific FCER2 Monoclonal Antibody (2A7)
인간 CD23(FcεRII) 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot 및 ELISA에 적합합니다. 고순도 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4) 용액 형태로 제공됩니다. B 세포 성장과 IgE 관련 연구에 활용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A7 |
| Immunogen | FCER2 (AAH14108, 1–321 a.a.) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT QGLKQLEERA ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ RLKSQDLELS WNLNGLQADL SSFKSQELNE RNEASDLLER LREEVTKLRM ELQVSSGFVC NTCPEKWINF QRKCYYFGKG TKQWVHARYA CDDMEGQLVS IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV DYSNWAPGEP TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM GPDSRPDPDG RLPTPSAPLH S
Target Information
CD23 is a 45 kDa glycoprotein present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts.
It is identical to the low-affinity IgE receptor found on B cells.
Expression of CD23 is detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases of centroblastic/centrocytic lymphoma.
Functionally, CD23 is involved in B cell growth and differentiation and IgE production.
A soluble form of CD23 acts as a potent mitogenic factor.
Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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