Thermo Fisher Scientific IL-6 Monoclonal Antibody (MQ2-13A5), Functional Grade, eBioscience

Applications

Product Specifications

Additional Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• eFluor 450
• FITC
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

Description:
The MQ2-13A5 antibody reacts with human interleukin-6 (IL-6), a 21–28 kDa cytokine secreted by multiple cell types.

Applications Reported:

• Cytokine neutralization
• ELISPOT
• ELISA capture

Applications Tested:
Tested for neutralizing IL-6 binding and biological activity.

Storage and Handling:
Use in a sterile environment.

Filtration:
0.2 µm post-manufacturing filtered.

Purity:

90%, determined by SDS-PAGE.

Endotoxin Level:
<0.001 ng/µg antibody (LAL assay).

Aggregation:
<10%, determined by HPLC.

Target Information

IL-6 encodes a cytokine involved in inflammation and B cell maturation. It acts as an endogenous pyrogen, inducing fever during autoimmune diseases or infections. Expressed mainly at inflammation sites, IL-6 triggers transcriptional inflammatory responses via the interleukin 6 receptor alpha. It is associated with diseases such as diabetes mellitus susceptibility, systemic juvenile rheumatoid arthritis, Kaposi sarcoma, and rheumatoid arthritis. Elevated IL-6 levels are also observed in viral infections including COVID-19 (SARS-CoV-2).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.