Thermo Fisher Scientific CD83 Polyclonal Antibody
CD83 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응. WB, IHC, Flow, ELISA에 사용 가능하며, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공. 연구용으로만 사용.
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Thermo Fisher Scientific CD83 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Flow Cytometry (Flow) | 1:20 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CD83 (amino acids 32–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD83 cell surface antigen is a 40–45 kDa glycoprotein expressed by peripheral blood dendritic cells. Peripheral lymphocytes can be induced to express low levels of CD83 after culture in agents such as Con A or PHA.
In immunohistology, CD83 is strongly expressed by interfollicular interdigitating reticulum cells and weakly by cells within germinal centres. It is also expressed by Langerhans cells in the skin.
The CD83 antigen is a 186-amino-acid single-chain glycoprotein belonging to the immunoglobulin superfamily, composed of an extracellular V-type Ig-like domain, a transmembrane region, and a short cytoplasmic tail. CD83 undergoes extensive post-translational glycosylation, resulting in a molecular weight approximately twice that of the core protein.
CD83⁺ cells exhibit a unique surface immunophenotype distinct from T, B, NK, or myelomonocytic cells, coexpressing high levels of MHC class II molecules and various lineage markers (CD2, CD5, CD40, CD78, CD13, CD33, CD36) as well as cytokine receptors.
Diseases associated with CD83 dysfunction include plague and Rift Valley Fever.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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