Thermo Fisher Scientific LYVE1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LYVE1 for research use. Validated in WB and IHC(P) applications. Affinity purified and supplied as liquid in PBS with glycerol. Ideal for lymphatic vessel marker studies.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LYVE1. Recombinant protein control fragment (Product #RP-102930). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856578 |
Product Specific Information
Immunogen sequence:
FETCSYGWVG DGFVVISRIS PNPKCGKNGV GVLIWKVPVS RQFAAYCYNS SDTWTNSCIP EIITTKDPIF NTQTATQTTE FIVSDSTYSV ASPYSTIPAP TTTPPAPAST SIPRRKKLIC VTEVFMETST MSTETEPFVE NKAAFKNEAA
Target Information
LYVE1 has been identified as a major receptor for hyaluronan (HA) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide, 41% similar to the CD44 HA receptor, with a 212-residue extracellular domain containing a single Link module—the prototypic HA binding domain of the Link protein superfamily.
Like CD44, LYVE1 binds both soluble and immobilized HA, but unlike CD44, LYVE1 colocalizes with HA on the luminal face of lymph vessels and is absent from blood vessels.
LYVE1 serves as a lymph-specific HA receptor and a powerful marker for lymphatic vessels. It is a type I integral membrane glycoprotein expressed primarily on lymphatic endothelium and may regulate leukocyte and tumor cell trafficking to lymph nodes.
Markers for lymphatic endothelium include LYVE1, PALE, VEGFR3, and podoplanin.
Diseases associated with LYVE1 dysfunction include Complete Androgen Insensitivity Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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