Thermo Fisher Scientific Phospho-p53 (Ser9) Polyclonal Antibody
인간 p53 단백질의 Ser9 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot, ELISA, IP에 사용 가능. 높은 특이성과 재현성을 제공하며, 세포 스트레스 관련 p53 신호 연구에 적합. -20°C 보관, 연구용 전용.
- 카탈로그번호
- PA5110141
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-p53 (Ser9) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphorylated peptide around S9 of human p53 (NP_000537.3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.31 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855552 |
Product Specific Information
Immunogen sequence: DPSVE
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation. Upon activation, p53 induces expression of genes such as p21waf1, leading to G1 or G2/M arrest.
The structure of p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at sites such as Ser15 and Ser392 regulates activation and stabilization, with Ser392 phosphorylation associated with tumor formation. p53 is expressed at low levels in normal cells but is upregulated in transformed cells, contributing to malignancy. Mutations in the TP53 gene cause loss of tumor suppressor activity and are common in many cancers, including hereditary syndromes like Li-Fraumeni.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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