Thermo Fisher Scientific GRF-1 Polyclonal Antibody
Rabbit 유래의 GRF-1 폴리클로날 항체로 Western blot에 최적화되어 있습니다. 인간, 마우스, 랫트, 햄스터에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. -20°C 보관하며 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to central residues of human p190-A RhoGAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20 °C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981914 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
RNA polymerase (pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA, and is overexpressed in many transformed cell lines and tumors in vivo. To maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex (TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, TFIIIC63) is overexpressed in adenovirus-transformed and malignant cells such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may play a key role in malignant cell deregulation.
The TFIIIB complex includes TATA-binding protein (TBP), TFIIB-related factor 1 (TFIIIB90, BRF1), and TFIIIB, which are also upregulated in transformed cells. In many carcinomas, tumor suppressors retinoblastoma (RB) and p53 are inactivated, affecting their ability to bind and inactivate TFIIIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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