Thermo Fisher Scientific LDLR Recombinant Rabbit Monoclonal Antibody (004)
마우스 LDLR 단백질을 인식하는 재조합 토끼 단클론 항체. 높은 특이성과 민감도를 제공하며, 로트 간 일관성이 우수함. 보존제가 없는 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- MA529724
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LDLR Recombinant Rabbit Monoclonal Antibody (004)
Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:20–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 004 |
| Immunogen | Recombinant Mouse LDLR Protein (Met1–Arg790) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | No preservative |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2785547 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, and the best clones are selected for production.
Advantages of recombinant rabbit monoclonal antibodies:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
This antibody is specific for Mouse LDLR.
Target Information
The low-density lipoprotein receptor (LDLR) gene family encodes cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL binds to the receptor at the cell membrane and is internalized, leading to degradation in lysosomes and release of cholesterol. This process regulates cholesterol synthesis by repressing HMG-CoA reductase and stimulating cholesterol ester synthesis.
Mutations in the LDLR gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDLR, along with SCARB1, CLDN1, and CD81, has been identified as an entry factor for the Hepatitis C virus. At least three isoforms of LDLR are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.