Thermo Fisher Scientific TOMM22 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR SAAGATFDLS LFVAQK

Highest antigen sequence identity to the following orthologs:

• Mouse: 92%
• Rat: 89%

Target Information

Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge.
The following functions can be assigned to the three domains of Tom22:

• The cytosolic N-terminal domain plays a dual role, specifically important for presequence binding.
• The intermembrane space domain provides a trans binding site for presequences.
• The single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex.

The TOM complex of mammalian mitochondria resembles the fungal Tom complex but is distinct from the plant TOM system. While unique components of the mammalian mitochondrial import system have been identified (e.g., TOM34 and metaxin), Tom22 and Tom37 have not been identified in plant mitochondria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.