Thermo Fisher Scientific DACT1 Polyclonal Antibody
Human DACT1 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 기반 버퍼에 40% 글리세롤 포함. Wnt 신호전달 연구 및 Dvl 단백질 상호작용 분석에 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DACT1 (Product #RP-88940) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640367 |
Product Specific Information
Immunogen sequence:
VPLPYASPYA YVASDSEYSA ECESLFHSTV VDTSEDEQSN YTTNCFGDSE SSVSEGEFVG ESTTTSDSEE SGGLIWSQFV QTLPIQTVTA PDLHNHPAKT FVKIKASHNL KKKILRFRSG S
- Highest antigen sequence identity to orthologs:
- Mouse: 95%
- Rat: 93%
Target Information
Dapper homolog 1 (DACT1), an ortholog of Xenopus Dpr, antagonizes Wnt signaling by promoting Dvl degradation via a lysosome inhibitor-sensitive and proteasome inhibitor-insensitive mechanism.
It interacts with Dvl through the DEP (Dishevelled, Egl-10, and pleckstrin) domain and the central/C-terminal regions of DACT1.
The human DACT1 gene is located on chromosome 14q23.1.
This protein impedes CTNNB1/beta-catenin degradation, enhancing transcriptional activation of Wnt pathway target genes.
It is essential for normal notochord formation and is downregulated in hepatocellular carcinoma (HCC).
Expression is observed in human liver and various other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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