Thermo Fisher Scientific ULBP1 Polyclonal Antibody
Thermo Fisher Scientific의 ULBP1 Polyclonal Antibody는 Human ULBP1 단백질을 인식하는 Rabbit IgG 항체입니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–234 of Human ULBP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549550 |
Product Specific Information
- Recommended positive control: K562
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
ULBP1 is a ligand for the NKG2D receptor, along with ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, inducing cytokine and chemokine production. Binding of ULBPs to NKG2D triggers calcium mobilization and activation of JAK2, STAT5, ERK, and PI3K/Akt pathways.
In CMV-infected cells, ULBP1 interacts with CMV glycoprotein UL16, which blocks NKG2D binding and retains ULBP1 in the ER and cis-Golgi, preventing its expression on the cell surface.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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