Thermo Fisher Scientific Nkx6.1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NKX6.1 for WB, IHC, and ELISA applications. High specificity and affinity-purified. Suitable for studying pancreatic beta-cell and CNS transcriptional regulation. Supplied in liquid form with glycerol for stab...
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human NKX6-1 (NP_006159.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.85 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914296 |
Product Specific Information
- Positive test controls: BxPC-3, Rat pancreas
- Immunogen sequence:
MLAVGAMEGT RQSAFLLSSP PLAALHSMAE MKTPLYPAAY PPLPAGPPSS SSSSSSSSSP SPPLGTHNPG GLKPPATGGL SSLGSPPQQL SAATPHGIND
Target Information
NKX6.1 is a bi-functional transcription factor active in both the central nervous system and pancreas. It regulates gene expression for motoneuron, oligodendrocyte, and insulin-secreting beta cell formation. NKX6.1 interacts with Pax6 and Pdx-1 near the homeobox DNA-binding domain, making it a key target for diabetes and neurological disease research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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