Thermo Fisher Scientific PKNOX2 Polyclonal Antibody
PKNOX2 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체. 인간 및 생쥐 시료에 반응하며 WB와 ICC/IF에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 1 mg/mL 농도. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5101239
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PKNOX2 (Accession Q96KN3), corresponding to amino acid residues H369–Q419 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850680 |
Product Specific Information
Antibody detects endogenous levels of total PKNOX2.
Target Information
PREP-2 (Pbx-regulating protein-2), also known as PBX/knotted 1 homeobox 2 or PKNOX2, is a widely expressed protein belonging to the TALE (three amino acid loop extension)/MEIS family.
PREP-2 is a DNA-binding protein that forms stable complexes with Pbx proteins. It is highly homologous to the related protein PREP-1, but displays a more restricted tissue distribution and a higher DNA-dissociation rate.
Like PREP-1, PREP-2 forms a heterodimer with Pbx 1. The PREP-2–Pbx 1 dimer relocates to the nucleus where it associates with HoxB1 to form a ternary complex.
In contrast with PREP-1, which acts to increase transcriptional activation in this ternary complex, PREP-2 leads to a slight decrease in transcriptional activity.
Multiple isoforms exist for PREP-2, localizing to the nucleus or cytoplasm. Cytoplasmic isoforms are believed to colocalize with F-actin, G-actin, and tubulin/microtubules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-101239_PKNOX2_Q96KN3-1_Rabbit.svg, PA5-101239_PKNOX2_Q96KN3-1_Rabbit_PDP.jpeg)
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