Thermo Fisher Scientific LMTK3 Polyclonal Antibody
LMTK3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, Affinity chromatography로 정제되었습니다. PBS/glycerol buffer에 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LMTK3 (Accession Q96Q04), corresponding to amino acid residues R674–P724 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2850681 |
Product Specific Information
Antibody detects endogenous levels of total LMTK3.
Target Information
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation.
May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804).
Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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