Thermo Fisher Scientific SMPD4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human SMPD4. Recombinant protein control fragment (Product #RP-98452). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SMPD4,uniProtId:Q9NXE4-1,ncbiNodeId:9606,antigenRange:596-699,antigenLength:866,antigenImageFileName:PA5-61966_SMPD4_Q9NXE4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61966_SMPD4_Q9NXE4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2647661

Product Specific Information

Immunogen sequence: LAQLITQAKH TAKSISDQCA ESPAGHSFLS WLGFSSMDTN GSYTANDLDE MGQDSVRKTD EYLEKALEYL RQIFRLSEAQ LRQFTLALGT TQDENGKKQL PDCI

Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 84%.

Target Information

The protein encoded by SMPD4 is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.