Thermo Fisher Scientific PCGF1 Polyclonal Antibody
Human, Mouse, Rat에 반응하는 Rabbit Polyclonal Antibody로 Western blot에 적합. KLH 결합 합성 펩타이드(117-151 aa)로 면역화. Protein A 및 항원 친화 크로마토그래피로 정제. PBS 버퍼에 0.09% sodium azide 포함, 4°C 또는 -20°C 보관.
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- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 117–151 amino acids from the central region of human PCGF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2634844 |
Product Specific Information
Predicted to react with bovine based on sequence homology.
Target Information
Component of the Polycomb group (PcG) multiprotein BCOR complex, required to maintain the transcriptionally repressive state of certain genes such as BCL6 and CDKN1A.
Acts as a transcriptional repressor possibly targeted to DNA by BCL6, related to PKC signaling pathway.
Represses CDKN1A expression by binding to its promoter, dependent on the retinoic acid response element (RARE).
Promotes cell cycle progression and proliferation; may contribute to tumor growth by down-regulating CDKN1A.
Also part of a PcG PRC1-like complex that mediates monoubiquitination of histone H2A (Lys-119), leading to heritable chromatin modification and gene repression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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