Thermo Fisher Scientific TRBC1 Polyclonal Antibody

Thermo Fisher Scientific TRBC1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1:1,000
Publications: - (No references listed)

Product Specifications

Target Information

Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen-specific receptors essential to the immune response and are present on the surface of T lymphocytes. They recognize peptide-major histocompatibility (pMH) complexes displayed by antigen-presenting cells (APC), which is critical for adaptive immunity against pathogens (PubMed:25493333).

Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering and activation of LCK, which phosphorylates ITAM motifs of CD3G, CD3D, CD3E, and CD247, enabling recruitment of ZAP70. ZAP70 phosphorylates LAT, forming the LAT signalosome that propagates signaling through calcium, MAPK, and NF-kappa-B pathways. These pathways activate transcription factors crucial for T cell growth and differentiation (PubMed:9382891, PubMed:23524462).

T cell repertoire is generated in the thymus by V-(D)-J rearrangement and shaped by intrathymic selection to produce self-MH restricted, non-autoaggressive T cells. Post-thymic interactions of alpha-beta TR with pMH complexes further refine TR structural and functional avidity (PubMed:15040585). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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