Thermo Fisher Scientific PRRX1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

• This antibody is expected to recognize both reported isoforms (NP_008833.1; NP_073207.1).
• Tested in Peptide ELISA: antibody detection limit dilution 1:2,000.

Target Information

The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species and functions to bind DNA via a helix-turn-helix structure, playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.