Thermo Fisher Scientific PRRX1 Polyclonal Antibody
PRRX1 단백질을 인식하는 Thermo Fisher Scientific의 다클론 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot에 적합하며, 액상 형태로 제공됩니다. TBS(pH 7.3) 버퍼에 0.5% BSA와 0.02% sodium azide가 포함되어 있습니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–3 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-QADENVGEAGRS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932962 |
Product Specific Information
- This antibody is expected to recognize both reported isoforms (NP_008833.1; NP_073207.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:2,000.
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species and functions to bind DNA via a helix-turn-helix structure, playing a role in transcriptional regulation and gene expression control.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox DNA-binding domain, belonging to the paired homeobox family.
Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression induced by growth and differentiation factors.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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