Thermo Fisher Scientific ROCK1 Polyclonal Antibody
ROCK1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 적합. Human과 Mouse에 반응하며 Rat, Rabbit에서도 예측 반응. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000–1:15,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1300 and the C-terminus (residue 1354) of Human Rho-associated, coiled-coil containing protein kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Rabbit
Target Information
ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration. The Rho/ROCK pathway is involved in the progression of various human cancers. ROCK1 has been identified as a Caspase-3 substrate and contributes to myosin light chain (MLC) activation through direct phosphorylation and inhibition of MLC phosphatase. During apoptosis, ROCK1 is cleaved by caspase-3, leading to constitutive kinase activity and membrane blebbing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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