Thermo Fisher Scientific Cystatin 2 Polyclonal Antibody
인체 유래 Cystatin 2 단백질을 인식하는 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 고순도의 Affinity chromatography 정제 항체. 액상 형태로 1 mg/mL 농도, PBS 및 50% glycerol 보존, -20°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CST2 (Accession P09228), corresponding to amino acid residues C6–N56 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899693 |
Product Specific Information
Antibody detects endogenous levels of total CST2.
Target Information
The cystatin superfamily is a well-established family of cysteine protease inhibitors.
Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN, and SA are extracellular (type 2); and the kininogens are type 3 cystatins, which are intravascular proteins.
All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes.
Cystatin SA, S, and SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine, and seminal fluid. Cystatin C is expressed in brain, thymus, ovary, epididymis, and vas deferens.
Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins.
The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulate insulin and hepatocyte growth factor receptors, and mediate systemic inflammation responses.
High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) both inhibit thrombin- and plasmin-induced thrombocyte aggregation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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