Thermo Fisher Scientific SPANXB1 Monoclonal Antibody (OTI1E11)
SPANXB1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체. Western blot과 IHC(P)에서 검증됨. 인간 시료에 반응하며, 고순도 친화 크로마토그래피로 정제됨. 연구용으로 정자 형성과정 및 SPANX 계열 단백질 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E11 |
| Immunogen | Full length human recombinant protein of SPANXB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725402 |
Target Information
Temporally regulated transcription and translation of several testis-specific genes are required to initiate the molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa.
This gene is a member of the SPANX family of cancer/testis-associated genes, located in a cluster on chromosome X. The SPANX genes encode testis-specific proteins that localize to various subcellular compartments.
SPANXB1 maps to chromosome X in a head-to-tail orientation with SPANX family member B2, which appears to be a duplication of the B1 locus. The SPANXB genes contain an additional 18 nt in their coding region compared to most other family members.
Although the protein encoded by this gene has consensus nuclear localization signals, its major localization site is in the cytoplasmic droplets of ejaculated spermatozoa. This protein serves as a biochemical marker for studying sperm structure and spermatogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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