Thermo Fisher Scientific p38 MAPK Polyclonal Antibody
p38 MAPK 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA, IP 등 다양한 실험에 사용 가능. 세포 스트레스 및 염증 반응 연구에 적합하며, 비결합(Unconjugated) 형태로 제공됨. -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:1,500–1:50,000 |
| ELISA | 1:25,000–1:50,000 |
| Immunoprecipitation (IP) | 0.2–1 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human p38 alpha / MAPK14 Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other stimuli. p38 MAPK is inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and affinities for upstream activators and downstream effectors. Activation occurs upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, leading to phosphorylation of MAPK kinase-3/6, which in turn phosphorylate Thr180 and Tyr182 in p38 MAPK. Activated phospho-p38 MAPK then phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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