Thermo Fisher Scientific p38 MAPK Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other stimuli. p38 MAPK is inactive in its nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and affinities for upstream activators and downstream effectors. Activation occurs upon exposure to tumor necrosis factor, interleukin-1, heat shock, or other stimuli, leading to phosphorylation of MAPK kinase-3/6, which in turn phosphorylate Thr180 and Tyr182 in p38 MAPK. Activated phospho-p38 MAPK then phosphorylates transcription factors such as ATF-2, CHOP-1, and MEF-2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.