Thermo Fisher Scientific ATP6V0A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100% | Horse: 93% | Human: 86% | Mouse: 100% | Pig: 100% | Rabbit: 93% | Rat: 100%

Target Information

ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase–dependent organelle acidification is necessary for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase is composed of:

• V1 domain (cytosolic): 3 A, 3 B, 2 G subunits plus C, D, E, F, and H subunits (contains ATP catalytic site)
• V0 domain (transmembrane): 5 subunits (a, c, c’, c”, d)

Additional isoforms are encoded by multiple genes or alternatively spliced transcript variants.
This gene encodes one of three A subunit proteins and is associated with clathrin-coated vesicles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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