Thermo Fisher Scientific MORF4L2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1.25 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 5 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
MSSRKQGSQP RGQQSAEEEN FKKPTRSNMQ RSKMRGASSG KKTAGPQQKN

Sequence homology:
Cow: 85%
Dog: 92%
Guinea Pig: 85%
Horse: 92%
Human: 100%
Mouse: 92%
Pig: 92%
Rabbit: 92%
Rat: 92%
Yeast: 91%

Target Information

MORF4L2 is a protein coding gene. It is a component of the NuA4 histone acetyltransferase complex, which participates in transcriptional activation of select genes primarily through acetylation of nucleosomal histone H4 and H2A. This modification can alter nucleosome–DNA interactions and facilitate binding of modified histones with transcription-regulating proteins.
The NuA4 complex is associated with processes such as oncogene-mediated growth induction, tumor suppressor-mediated growth arrest, replicative senescence, apoptosis, and DNA repair. The ATPase and helicase activities of the complex are partially contributed by RUVBL1 and RUVBL2 in association with EP400. Additionally, NuA4 may directly participate in DNA repair when recruited to sites of damage. MORF4L2 is also part of the MSIN3A complex, which represses transcription via histone deacetylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.