Thermo Fisher Scientific NEDD4 Recombinant Rabbit Monoclonal Antibody (23GB2255)
NEDD4 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 사용 가능. 인간, 마우스, 랫트 반응성. HEK293F 발현, Affinity chromatography로 정제. -20°C 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2255 |
| Immunogen | A synthesized peptide derived from human NEDD4 (1271–1319 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains. It participates in the degradation pathway of VEGFR-2/KDFR, independent of its ubiquitin-ligase activity.
NEDD4 acts as a potential proto-oncogene by negatively regulating PTEN through ubiquitination, analogous to the Mdm2–p53 relationship. It is also involved in viral budding and regulates epithelial Na⁺ channels, contributing to arterial hypertension.
NEDD4 localizes to the sarcolemmal region of muscle fibers; its increased expression is associated with muscle unloading and denervation, as well as decreased Notch1 expression, thus acting as a downregulator of Notch-1 gene expression.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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