Thermo Fisher Scientific CD26 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1.25–2.5 µg/mL

Product Specifications

Product Specific Information

Percent identity with other species by BLAST analysis:
Human, Chimpanzee, Gorilla, Gibbon, Monkey, Bat, Bovine, Horse, Rabbit, Pig (100%)
Orangutan, Galago, Cat (94%)

Target Information

CD26 (dipeptidyl peptidase IV, DPP IV; adenosine deaminase (ADA) binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family.
CD26 is expressed on lymphocyte cells and is upregulated during T-cell activation. It is also expressed on activated B cells, natural killer cells, and epithelia.
CD26 participates in various biological functions including:

• T-cell activation
• Cell adhesion with extracellular matrix (fibronectin, collagens)
• HIV infection

CD26 is identical to ADA complexing protein-2 and T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
Alterations in CD26 peptidase activity are linked to malignant transformation, with enzymatic activity increasing with tumor grade and severity.
CD26 is expressed in various blood cell types and in cells histogenetically related to activated fibroblasts.
Changes in CD26 density have been reported on circulating monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.