Thermo Fisher Scientific IARS2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:50

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IARS2. Recombinant protein control fragment (Product #RP-94008). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IARS2,uniProtId:Q9NSE4-1,ncbiNodeId:9606,antigenRange:506-595,antigenLength:1012,antigenImageFileName:PA5-55118_IARS2_Q9NSE4-1_Rabbit.svg,antigenImageFileNamePDP:PA5-55118_IARS2_Q9NSE4-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642607

Product Specific Information

Immunogen sequence: ALNGMVEMMD RRPYWCISRQ RVWGVPIPVF HHKTKDEYLI NSQTTEHIVK LVEQHGSDIW WTLPPEQLLP KEVLSEVGGP DALEYVPGQD

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 84%.

Target Information

The Trip230 gene encodes a protein of 1,978 amino acids with an estimated molecular mass of 230 kDa. The gene is located on chromosome 14q31, which is in a region associated with genetic alterations and thyroid hormone response abnormalities. The Trip230 protein interacts with Rb and thyroid hormone receptor (TR) using two distinct domains. Complex formation with Rb is in a hormone independent manner, but when Trip230 forms a complex with TR, it is in a thyroid hormone-dependent manner. After T3 treatment, Trip230 is phosphorylated and transported to the nucleus, suggesting that phosphorylation may be important for its nuclear translocation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.