Thermo Fisher Scientific LRP2 Polyclonal Antibody
LRP2 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC에 적합. Human, Mouse, Rat 시료 반응성. 합성 펩타이드 면역원으로 제작되었으며, 액상 형태로 제공. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:50–1:200 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human LRP2 (UniProt ID: P98164-1, antigen range: 2927–2949) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.42% potassium phosphate (pH 7.3), 30% glycerol, 0.87% NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691779 |
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
The LRP2 (low density lipoprotein-related protein 2), also known as megalin, is a multi-ligand endocytic receptor expressed mainly in absorptive epithelial tissues such as the kidney.
This glycoprotein includes:
- A large amino-terminal extracellular domain
- A single transmembrane domain
- A short cytoplasmic tail
It binds various macromolecules including albumin, apolipoproteins B/E, and lipoprotein lipase.
LRP2 plays a critical role in the reuptake of ligands such as lipoproteins, sterols, vitamin-binding proteins, and hormones.
It also participates in cell-signaling, interacting with extracellular ligands (e.g., parathyroid hormones, sonic hedgehog) and intracellular partners (e.g., MAP kinase scaffold proteins, JNK interacting proteins).
Recycling of LRP2 is regulated by phosphorylation of its cytoplasmic domain.
Mutations in this gene are associated with Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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