Thermo Fisher Scientific GPR182 Polyclonal Antibody
GPR182 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤, 0.05% 아지드) 용액 형태로 제공. 인간 및 마우스 시료에 반응.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the N-terminal of human G protein-coupled receptor 182 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2636080 |
Product Specific Information
The antibody detects endogenous levels of total GPR182 / ADMR protein.
Target Information
Adrenomedullin (ADM) is a hypotensive peptide belonging to the peptide superfamily that includes calcitonin gene-related peptide (CGRP) and amylin. ADM was originally identified in the adrenal medulla, where it is highly expressed, and is also produced by most contractile cells. It is upregulated during sepsis and ischemia.
Three distinct receptors can bind ADM: ADM receptor (L1), RDC-1, and the Calcitonin Receptor-Like Receptor (CRLR). The CRLR associates with receptor activity-modifying proteins (RAMPs), which determine its binding specificity. Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or RAMP3 results in ADM binding.
The ADM receptor is a seven-transmembrane G protein-coupled receptor that specifically binds ADM and is highly expressed in heart, brain, skeletal muscle, immune system, adrenal gland, and liver. It mediates ADM signaling through G proteins that activate adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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