Thermo Fisher Scientific CBLN2 Polyclonal Antibody
CBLN2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 생쥐, 랫트 반응성. Protein A 정제, 고농도(1 mg/mL) 액상 형태로 -20°C 보관.
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Thermo Fisher Scientific CBLN2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CBLN2, amino acids 151–224 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1 (Cbln1). The precerebellin subfamily within the C1q protein family includes Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4). These proteins act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
Cerebellin and its metabolite des-Ser(1)Cer are expressed in extra-cerebellar tissues such as the adrenal gland. Cerebellin 1, 2, and 3 can form homomeric and heteromeric complexes, influencing each other’s degradation and secretion. Cerebellin 3 can only be secreted when forming a heteromeric complex with Cerebellin 1. Decreased Cerebellin levels have been observed in patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting its role in disease pathology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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