Thermo Fisher Scientific LRRTM2 Polyclonal Antibody
LRRTM2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC, ELISA 등에 사용 가능. Human, Mouse, Rat 시료에 반응하며, Protein A로 정제된 1 mg/mL 액상 제품. 신경계 시냅스 발달 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human LRRTM2 (amino acids 81–200) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and play key roles in synaptic development. LRRTM1 and LRRTM2 are particularly potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane protein containing ten extracellular leucine-rich repeats and a short intracellular tail, exhibiting unique developmental expression patterns.
LRRTM2 interacts with PSD-95 and regulates AMPA receptor surface expression. It also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting a critical role in excitatory synapse regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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