Thermo Fisher Scientific L1CAM Monoclonal Antibody (OTI1H3), TrueMAB
L1CAM/CD171 단백질을 표적하는 Mouse IgG1 단클론 항체로 신경계 발달 연구에 적합함. Western blot, ICC/IF, Flow cytometry, Immunoprecipitation 등 다양한 응용 가능. 고순도 친화 크로마토그래피로 정제된 액상 형태이며, 안정적인 보관용 PBS/BSA/glycerol 버퍼 포함.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2500–1:5000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
| Immunoprecipitation (IP) | 2–4 µg/mg |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H3 |
| Immunogen | Full-length human recombinant L1CAM protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. Its ectodomain consists of several immunoglobulin-like domains and fibronectin-like type III repeats, linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays a crucial role in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause three X-linked neurological syndromes collectively known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to have functional significance.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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