Thermo Fisher Scientific TMP21 Polyclonal Antibody
TMP21 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합. 인간, 생쥐, 랫드 시료에 반응. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
- 카탈로그번호
- OST00229W-100UL
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 5 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal of TMP21 (TEMP21, TMED10, Transmembrane protein Tmp21) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TMP21.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown TMP21’s association with this complex, suggesting its regulatory role. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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