Thermo Fisher Scientific TMP21 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TMP21.

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein. The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments have shown TMP21’s association with this complex, suggesting its regulatory role. Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.