Thermo Fisher Scientific TMP21 Polyclonal Antibody
TMP21 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot 및 IHC에 사용 가능하며, 단백질 수송 및 γ-secretase 조절 연구에 적합합니다. PBS 버퍼에 무보존제 상태로 제공되며, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
- 카탈로그번호
- OST00230G-500UG
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TMP21 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal of TMP21 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The antigen is homologous in many species including rat and mouse.
- Specificity: TMP21.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport.
It is part of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage of amyloid precursor protein (APP).
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1, which together cleave APP at γ- and ε-sites, leading to Abeta accumulation associated with Alzheimer’s disease.
Co-immunoprecipitation experiments indicate TMP21’s role in regulating this complex.
Suppression of TMP21 expression by siRNA increases γ-secretase activity and Abeta production, demonstrating TMP21’s modulatory function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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