Thermo Fisher Scientific SUMO1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1
• Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SUMO1 is an ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires activation by the E1 complex (SAE1-SAE2) and linkage to the E2 enzyme (UBE2I), promoted by E3 ligases such as PIAS1–4, RANBP2, or CBX4.
This post-translational modification plays a crucial role in cellular processes such as nuclear transport, DNA replication and repair, mitosis, and signal transduction.
SUMO1 targets RANGAP1 to the nuclear pore complex protein RANBP2 and may regulate genes involved in palate development. Mutations can lead to non-syndromic orofacial cleft 10.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.