Thermo Fisher Scientific BCL2L15 Recombinant Rabbit Monoclonal Antibody (4S4O7)
BCL2L15 단백질을 표적으로 하는 재조합 토끼 모노클로날 항체. Western blot과 ELISA에 적합하며, HEK293 세포에서 발현된 IgG 형식. Protein A로 정제된 액상 형태로, -20°C에서 보관. 세포사멸 관련 연구용으로 최적화된 항체.
- 카탈로그번호
- MA555396
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4S4O7 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–163 of human BCL2L15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
MKSSQTFEEQ TECIVNTLLM DFLSPTLQVA SRNLCCVDEV DSGEPCSFDV AIIAGRLRML GDQFNGELEA SAKNVIAETI KGQTGAILQD TVESLSKTWC AQDSSLAYER AFLAVSVKLL EYMAHIAPEV VGQVAIPMTG MINGNQAIRE FIQGQGGWEN LES
Target Information
Proteins of the Bcl-2 family are critical regulators of apoptosis.
Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1–3), while BH3-only proteins, like Bim, possess only the short BH3 motif.
Database searches revealed Bfk, an unusual novel member of the Bcl-2 family that contains BH2 and BH3 regions but not BH1 or BH4.
Bfk is thus most closely related to Bcl-G(L). It lacks a C-terminal membrane anchor and is cytosolic.
Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2’s prosurvival function.
Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins.
Low amounts of Bfk were found in stomach, ovary, bone marrow, and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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