Thermo Fisher Scientific Gephyrin Polyclonal Antibody
Rabbit polyclonal antibody recognizing human Gephyrin protein. Validated for WB, IHC (P), and ICC/IF. High specificity and affinity-purified. Supplied in liquid form with glycerol for stable storage. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution | Reference |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Gephyrin. Recombinant protein control fragment (Product #RP-89068). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2641960 |
Product Specific Information
Immunogen sequence:
SRCSSKENIL RASHSAVDIT KVARRHRMSP FPLTSMDKAF ITVLEMTPVL GTEIINYRDG MGRVLAQDVY AKDNLPPFPA SVKDGYAVRA ADGPGDRFII GESQAGEQPT QTVMPGQVMR VTTGAPIPCG ADAVVQVEDT
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high-affinity binding to receptor subunit domains and tubulin dimers. In non-neuronal tissues, it is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with hyperplexia and molybdenum cofactor deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been described, though not all full-length sequences are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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