Thermo Fisher Scientific USP13 Polyclonal Antibody
USP13 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. Human 시료에 반응하며, 고순도 친화 크로마토그래피 정제 제품입니다. PBS buffer, 50% glycerol로 안정화되어 장기 보관이 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific USP13 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein within Human USP13 aa 570–776 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.2% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2854679 |
Product Specific Information
Positive Control: 293T, Daudi, mouse testis tissue, rat brain tissue, A431, MG-63
Target Information
Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2, and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD).
Component of a regulatory loop that controls autophagy and p53/TP53 levels by mediating deubiquitination of BECN1, leading to stabilization of PIK3C3/VPS34-containing complexes.
Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. PIK3C3/VPS34-containing complexes regulate USP13 stability, suggesting a feedback system that controls p53/TP53 via USP10 and USP13.
Recruited by nuclear UFD1 and mediates deubiquitination of SKP2, regulating ERAD. Also regulates ERAD through deubiquitination of UBL4A, a BAG6/BAT3 complex component.
Mediates stabilization of SIAH2 independently of deubiquitinase activity by binding ubiquitinated SIAH2 and impairing its autoubiquitination.
Has weak deubiquitinase activity in vitro, preferentially cleaving Lys-63-linked polyubiquitin chains. Unlike USP5, it cannot mediate unanchored polyubiquitin disassembly.
Able to cleave ISG15 in vitro; however, further experiments are required to confirm this.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.