Thermo Fisher Scientific Phospho-p53 (Ser315) Polyclonal Antibody
Phospho-p53 (Ser315) 폴리클로날 항체로 인간 p53 단백질의 Ser315 인산화 부위를 특이적으로 인식. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, 고순도 친화 크로마토그래피 정제 및 액상 형태로 제공. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Phospho-p53 (Ser315) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Suggested Positive Control |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | HeLa cells |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | Human breast carcinoma |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 | HeLa cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 315 (S-S-S(p)-P-Q) derived from Human p53 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554366 |
Product Specific Information
- Suggested positive controls:
- WB: HeLa cells
- IHC: Human breast carcinoma
- ICC/IF: HeLa cells
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nutrient deprivation.
p53 up-regulates specific genes such as p21waf1, contributing to G1 or G2/M arrest. Structurally, it includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation of p53 at various sites, including Ser15 and Ser392, plays critical roles in activation, stabilization, and tumor formation. p53 is expressed at low levels in normal cells but highly in transformed cells, contributing to malignancy.
Mutations in TP53 lead to loss of tumor suppressor activity and are associated with multiple human cancers, including Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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