Thermo Fisher Scientific Phospho-Claudin 5 (Tyr217) Polyclonal Antibody
인간, 마우스, 랫트 반응성의 Rabbit Polyclonal 항체로 Tyr217 인산화 부위의 Claudin 5를 특이적으로 인식. 파라핀 절편 IHC에 적합하며, 인간 뇌 조직을 양성 대조로 권장. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific Phospho-Claudin 5 (Tyr217) Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y(p)-V) derived from Human Claudin 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554364 |
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in various malignancies, including breast, ovarian, hepatocellular, urinary, prostate, lung, head and neck, and thyroid cancers. Alternatively spliced transcript variants encoding different isoforms have been found.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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