Thermo Fisher Scientific CD6 Recombinant Rabbit Monoclonal Antibody (4H14L18)

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Dog, and Rabbit.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to rabbit immune repertoire

Target Information

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
It interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and functions as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may regulate CD5 signaling, and ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.