Thermo Fisher Scientific CD6 Recombinant Rabbit Monoclonal Antibody (4H14L18)
Human CD6 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot에 최적화되어 있습니다. Expi293 시스템에서 발현되며 높은 특이성과 재현성을 제공합니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 제품입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4H14L18 |
| Immunogen | Peptides corresponding to human CD6 (aa220–aa237, aa641–aa658) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2762403 |
Product Specific Information
This antibody is predicted to react with Monkey, Dog, and Rabbit.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells.
It interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and functions as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may regulate CD5 signaling, and ligation of CD6 has an anti-apoptotic role in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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