Thermo Fisher Scientific AMRA1 Polyclonal Antibody
AMBRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며 사람과 마우스 시료에 반응. 합성 펩타이드 기반 면역원 사용, 동결건조 형태로 제공. 연구용 전용 제품.
- 카탈로그번호
- OSA00072W-150UL
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:200–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:200–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of human Activating molecule in BECN1 regulated autophagy protein 1 (AMBRA1, AMRA1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in mouse.
- Specificity: AMBRA1.
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important for normal growth control and may be defective in tumor cells. It helps preserve cellular nutrients under starvation conditions and regulates turnover of cytosolic components.
Beclin-1, a principal regulator of autophagosome formation, is regulated by Ambra1. Ambra1 associates with Beclin-1 through a central region as determined by yeast two-hybrid assay.
Null mutations in this gene in mice lead to embryonic lethality with severe neural tube defects, impaired autophagy, accumulation of ubiquitinated proteins, unbalanced cell proliferation, and excessive apoptosis.
Down-regulation of Ambra1 via RNA interference reduces rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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