Thermo Fisher Scientific SCN4A Polyclonal Antibody
SCN4A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF에 사용 가능하며 인간, 생쥐, 랫트 반응성. 고순도 Affinity 정제, 액상 형태로 -20°C 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SCN4A (Accession P35499), corresponding to amino acid residues Y450–Q470 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2851323 |
Product Specific Information
Antibody detects endogenous levels of total SCN4A.
Target Information
Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, rapidly depolarizing the cell.
These channels consist of a pore-forming alpha subunit, a noncovalently associated beta1 subunit, and a disulfide-linked beta2 subunit. The beta subunits regulate channel expression, modulate gating, and function as cell adhesion molecules.
Alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons.
Impaired voltage-gated sodium channels are associated with diseases such as myotonia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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