Thermo Fisher Scientific SCN4A Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total SCN4A.

Target Information

Voltage-gated sodium channels are selective ion channels that regulate the permeability of sodium ions in excitable cells. During the propagation of an action potential, sodium channels allow an influx of sodium ions, rapidly depolarizing the cell.
These channels consist of a pore-forming alpha subunit, a noncovalently associated beta1 subunit, and a disulfide-linked beta2 subunit. The beta subunits regulate channel expression, modulate gating, and function as cell adhesion molecules.
Alpha subunits of sodium channels type I and III are predominantly expressed in neuronal cell bodies and proximal processes, while type II alpha subunits are more abundant along axons.
Impaired voltage-gated sodium channels are associated with diseases such as myotonia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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